Browsing by Author "Sokolova, A"
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- Acute Hemorrhagic Edema of InfancyPublication . Garcia, C; Sokolova, A; Torre, ML; Amaro, CAcute Hemorrhagic Edema of Infancy is a small vessel leucocytoclastic vasculitis affecting young infants. It is characterized by large, target-like, macular to purpuric plaques predominantly affecting the face, ear lobes and extremities. Non-pitting edema of the distal extremities and low-grade fever may also be present. Extra-cutaneous involvement is very rare. Although the lesions have a dramatic onset in a twenty-four to forty-eight hour period, usually the child has a non-toxic appearance. In most cases there are no changes in laboratory parameters. The cutaneous biopsy reveals an inflammatory perivascular infiltrate. It is a benign and auto-limited disease, with complete resolution within two to three weeks leaving no sequelae in the majority of cases. No recurrences are described. We report a case of a 42-day old girl admitted at our hospital with Acute Hemorrhagic Edema of Infancy.
- Alergia ao diospiroPublication . Pité, H; Sokolova, A; Bartolomé, B; Martins, P; Prates, S; Pinto, PA alergia ao dióspiro é rara, não estando identificados os alergénios envolvidos. Descreve -se o caso de uma doente de 24 anos, com história pessoal de rinite alérgica, sensibilizada a ácaros e a pólen de gramíneas, que refere a ocorrência de dois episódios de início súbito de prurido e edema labial, seguidos de tonturas, dor abdominal e vómitos persistentes, minutos após a ingestão de dióspiro, fruto que anteriormente tolerava. O teste cutâneo por picada com este fruto em natureza foi positivo, bem como o doseamento de IgE específica. No immunoblotting com extracto de dióspiro identificou- -se uma banda de 40 kDa. A alergia ao dióspiro pode ser grave. Os resultados obtidos apoiam o diagnóstico de anafilaxia a dióspiro mediada por IgE. A proteína de 40 kDa pode constituir um alergénio major do dióspiro, dado que bandas com pesos moleculares similares foram identificadas em cinco do total dos oito casos documentados na literatura.
- Anafilaxia ao frioPublication . Costa, F; Carvalho, R; Sokolova, A
- Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic OptionsPublication . Lopes, A; Sokolova, A; Abreu, C; Lopes, CAtopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was granted approval for treatment of moderate-to-severe AD. Biologics targeting IgE/Th2 pathways may have its role in patients with overlapping AD and asthma. Psychological distress can exacerbate symptoms and is associated with increased severity of AD. Environmental triggers, such as, allergens can be addressed in selected cases with allergic immunotherapy. In this paper, we discuss AD treatment and propose a new step-by-step approach aiming at maintaining disease control and improving quality of life.
- Edema agudo hemorrágico da infânciaPublication . Garcia, C; Sokolova, A; Torre, ML; Amaro, C
- Proctocolite induzida por proteína alimentar em lactente sob aleitamento materno exclusivoPublication . Prelhaz, C; Sokolova, A; Escobar, C; Moniz, M; Nunes, P; Abadesso, C; Loureiro, HIntrodução: A protocolite induzida por proteína alimentar é uma reação de hipersensibilidade não -IgE mediada, mais frequentemente desencadeada pela ingestão de leite de vaca ou soja mas também já reconhecida no contexto de aleitamento materno exclusivo. Pode manifestar -se nas primeiras semanas de vida e o seu diagnóstico constitui um desafio pela inespecificidade das manifestações clínicas, muitas vezes levando a intervenções médicas desnecessárias e invasivas. Caso clínico: Os autores apresentam um lactente com um mês de vida sob aleitamento materno exclusivo, avaliado por dejeções hemáticas, recusa alimentar e irritabilidade, cuja investigação clínica foi consecutivamente negativa e cujas manifestações clínicas reverteram após evicção do leite materno e início de leite extensamente hidrolizado. Conclusões: A evicção da proteína alimentar desencadeante resulta numa recuperação clínica geralmente completa e sem sequelas tardias. Pode ser necessária a suspensão do aleitamento materno em lactentes nos quais não seja identificada outra causa para a hipersensibilidade.
- The Portuguese Severe Asthma Registry: Development, Features, and Data Sharing PoliciesPublication . Sá-Sousa A1, A; Fonseca, JA; Pereira, AM; Ferreira, A; Arrobas, A; Mendes, A; Drummond, M; Videira, W; Costa, T; Farinha, P; Soares, J; Rocha, P; Todo-Bom, A; Sokolova, A; Costa, A; Fernandes, B; Loureiro, C; Longo, C; Pardal, C; Costa, C, et al.The Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation of RAG, its features, and data sharing policies. The contents and structure of RAG were defined in a multistep consensus process. A pilot version was pretested and iteratively improved. The selection of data elements for RAG considered other severe asthma registries, aiming at characterizing the patient's clinical status whilst avoiding overloading the standard workflow of the clinical appointment. Features of RAG include automatic assessment of eligibility, easy data input, and exportable data in natural language that can be pasted directly in patients' electronic health record and security features to enable data sharing (among researchers and with other international databases) without compromising patients' confidentiality. RAG is a national web-based disease registry of severe asthma patients, available at asmagrave.pt. It allows prospective clinical data collection, promotes standardized care and collaborative clinical research, and may contribute to inform evidence-based healthcare policies for severe asthma.