Browsing by Author "Rosa, A"
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- Catatonia como Apresentação de Doença de CreutzfeldtJakob: Um Caso ClínicoPublication . Fernandes, I; Carneiro, S; Duarte, M; Rosa, AIntrodução: A catatonia é uma síndrome neuropsiquiátrica, classicamente associada à esquizofrenia, mas mais frequentemente relacionada com outras causas psiquiátricas, neurológicas e/ou metabólicas. Caso Clínico: Um homem de 61 anos foi internado no Serviço de Psiquiatria por catatonia de etiologia a esclarecer. O electroencefalograma revelou actividade periódica trifásica e a ressonância magnética crânio-encefálica revelou atrofia cortico-subcortical de predomínio frontal e temporal interno. O doente foi transferido para o Serviço de Neurologia por provável encefalopatia espongiforme, com a detecção de um aumento da proteína 14.3.3 no líquor cefalorraquidiano. O quadro clínico agravou-se com mioclonias plurisegmentares, episódios de desvio ocular e distonia, culminando no óbito ao fim de 5 semanas. O estudo anatomopatológico confirmou o diagnóstico de Doença de Creutzfeldt-Jakob esporádica. Conclusões: Este caso reflecte a dificuldade no diagnóstico diferencial das doenças com sintomatologia neuropsiquiátrica, em particular da catatonia, e a importância da articulação e sinergismo multidisciplinar na Medicina.
- Comunicar na, com e em comunidade. Arquitectura(s) de uma equipaPublication . Rosa, A; Pinheiro, C; Santos, J; Gabriel, COs autores procuram reflectir sobre a sua experiência em Psiquiatria Comunitária num contexto e tempo desafiador, mas também capaz de induzir modos de fazer, no encontro entre o técnico de Saúde Mental e o paciente. Procura-se, numa intencionalidade multidisciplinar, integrar um corpo de conhecimentos (em vizinhança), que confere um sentido, inscrito num tempo e num espaço. Habitamos espaços únicos, desenhados por uma arquitectura em que a figura humana é ainda identificada e o programa permite a leitura da intersubjectividade.
- Depression, Anxiety and Alcohol Abuse in a Gastroenterology Intensive Care Unit: Prevalence and DetectionPublication . Cardoso, G; Alexandre, J; Rosa, AObjectives: To assess depression, anxiety, and alcohol abuse in a Gastroenterology ICU, and the level of its detection by the staff. Method: All patients consecutively admitted to the ICU during a six-month period, 18 or above, and staying 24 hours, were assessed with the Hospital Anxiety and Depression Scale (HADS) and the CAGE. Doctors and nurses assessed the type and severity of patients’ morbidity. Data were analyzed with Student’s t-test, Pearson’s and Spearman’s correlations for ordinal variables, chi-square for nominal variables, and multiple logistic regression. Results: The 65 patients assessed had a mean age of 57, and were predominantly male (58.5%), married (72.3%), and retired (53.8%); 27.7% had a psychiatric history, 24.6% were on psychotropic drugs, and 32.3% had an alcohol intake above standards. Anxiety and depression HADS scores 8 were present in 29.2% and 35.4% of the patients, respectively; 20%, mainly men, scored positive on the CAGE. Women had significantly higher anxiety scores (=.012) than men but did not differ in depression. A psychiatric history was significantly associated with higher anxiety (p<.001) and depression (p=.007) scores, as well as being on psychotropic drugs regularly (p<.001; p=.03, respectively). Doctors diagnosed somatic illness in 48.8%, and somatic illness with psychiatric co-morbidity in 51%; for nurses the rates were, respectively, 41.5% and 58.6%. Doctors’ and nurses’ detection of psychiatric disorders were significantly associated with the HADS anxiety scores (p=.013; p=.001, respectively), and doctor’s detection with depression (p=.046) scores. There were no significant associations between nurses’ detection of psychiatric disorders and depression, and between both professional groups detection and alcohol abuse. Conclusion: High prevalence of depression, anxiety, and alcohol abuse in Gastroenterology ICU was confirmed. However, the level of detection by the staff was low and mainly when anxiety symptoms were present.
- Estética da subversão e da violência nas obras de arte de Francis Bacon e Frida KahloPublication . Pinheiro, C; Dias, MJ; Rosa, AA partir das obras de Frida Kahlo e Francis Bacon, os autores discutem as dimensões da violência e do trauma presentes nas suas formas criativas e no impacto criado no espectador. Reflectem ainda sobre as suas ligações com a clínica no impacto/fenómeno contratransferencial e suas possibilidades transformacionais
- Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese patients.Publication . Rosa, A; Fonseca, B; Krug, T; Manso, H; Gouveia, L; Albergaria, I; Gaspar, G; Correia, M; Viana-Baptista, M; Simões, R; Pinto, A; Taipa, R; Ferreira, C; Fontes, J; Silva, M; Gabriel, J; Matos, I; Lopes, G; Ferro, J; Vicente, A; Oliveira, SBACKGROUND: The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to assess the contribution of mtDNA polymorphisms and haplogroups to ischemic stroke risk. METHODS: We genotyped 19 mtDNA single nucleotide polymorphisms (SNPs) defining the major European haplogroups in 534 ischemic stroke patients and 499 controls collected in Portugal, and tested their allelic and haplogroup association with ischemic stroke risk. RESULTS: Haplogroup H1 was found to be significantly less frequent in stroke patients than in controls (OR = 0.61, 95% CI = 0.45-0.83, p = 0.001), when comparing each clade against all other haplogroups pooled together. Conversely, the pre-HV/HV and U mtDNA lineages emerge as potential genetic factors conferring risk for stroke (OR = 3.14, 95% CI = 1.41-7.01, p = 0.003, and OR = 2.87, 95% CI = 1.13-7.28, p = 0.021, respectively). SNPs m.3010G>A, m.7028C>T and m.11719G>A strongly influence ischemic stroke risk, their allelic state in haplogroup H1 corroborating its protective effect. CONCLUSION: Our data suggests that mitochondrial haplogroup H1 has an impact on ischemic stroke risk in a Portuguese sample.
- Rash cutâneo tardio na terapêutica com lamotrigina: a propósito de um caso clínicoPublication . Ribeiro, R; Rosa, A; Maia, TO uso de Lamotrigina na Doença Bipolar está a p rovado desde 2003 pela F.D.A.. O rash é o efeito secundário mais comumente encontrado e é um motivo frequente de descontinuação do tratamento. Têm sido descritos casos raros de r a s h t a rdio. A propósito de um caso clínico, revêem-se os dados existentes na literatura, respeitantes à utilização de Lamotrigina em doentes bipolares dando-se principal enfoque ao rash, particularizando ainda alguns aspectos do rash com surgimento tardio, de que é exemplo o caso apresentado.