UCI - Artigos publicados em revistas não indexadas
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- Granulomatose de WegenerPublication . João, C; Santos, E; Leite, A; Miranda, C; Serra, I; Revés, L; Brandão, T; Martins, F; Freitas, PT; Dutschmann, LA granulomatose de Wegener corresponde a uma vasculite sistémica com atingimento das artérias de pequeno e médio calibre, em particular das vias aéreas superiores e inferiores e do rim, incluindo-se no diagnóstico diferencial das síndromas pulmão-rim. Os AA apresentam o caso clínico de uma senhora de 59 anos, internada na Unidade de Cuidados Intensivos Polivalente (UCIP) do Hospital Fernando da Fonseca com um quadro de insuficiência respiratória, hemoptises e insuficiência renal. Descreve-se o estudo etiológico desta situação, concluindo tratar-se de um caso de granulomatose de Wegener. A propósito deste caso são discutidos aspectos relevantes do diagnóstico, terapêutica e seguimento destes doentes.
- Triagem de Enfermagem na Urgência Geral de Adultos: uma realidade no Hospital Amadora-SintraPublication . Vieira, JO acolhimento e a triagem de doentes é um processo importante e único para cada doente, realizado por uma equipa multidisciplinar, sendo a principal preocupação a de acolher, encaminhar e estabelecer a prioridade de forma humanizada e individualizada, garantindo um atendimento rápido, pelo pessoal apropriado ná àrea clínica correcta.
- Mycoplasma pneumoniae causing nervous system lesion and SIADH in the absence of pneumoniaPublication . Coelho, M; Leite, A; Revés, A; Miranda, C; Serra, I; Brandão, T; Albuquerque, L; Freitas, PTA patient was admitted for fever and acute respiratory failure (ARF), rapidly progressive tetraparesis, delirium, behavioral abnormalities, and diplopia. Leukocytosis and a rise in C-reactive protein were present. A syndrome of inappropriate anti-diuretic hormone secretion (SIADH) was also diagnosed. Lumbar puncture yielded colorless CFS with mononuclear pleocytosis and protein rise. Electrodiagnosis revealed demyelinating polyneuropathy and axonal degeneration. Serum IgG and IgM for mycoplasma pneumoniae (MP) was consistent with acute infection, and erythromycin was started with rapid resolution of symptoms. Contrarily to most reports, an associated respiratory disease was not present and SIADH in association with MP has been reported only once, in a patient without direct central nervous system (CNS) involvement. Differential diagnosis and possible pathogenic mechanisms are discussed.
- Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilation.Publication . Tejerina, E; Frutos-Vivar, F; Restrepo, M; Anzueto, A; Palizas, F; Gonzaléz, M; Aspesteguía, C; Abroug, F; Matanis, D; Bugedo, G; Esteban, A; Freitas, PT; International Mechanical Ventilation Study GroupPURPOSE: To evaluate the variables associated with mortality of patients with community-acquired pneumonia who require mechanical ventilation and to determine the attributable morbidity and intensive care unit (ICU) mortality of community-acquired pneumonia. MATERIAL AND METHODS: Retrospective cohort study carried out in 361 ICUs from 20 countries including 124 patients who required mechanical ventilation on the first day of admission to the hospital due to acute respiratory failure secondary to severe community-acquired pneumonia. To assess the factors associated with outcome, a forward stepwise logistic regression analysis was performed, and to determine the attributable mortality of community-acquired pneumonia, a matched study design was used. RESULTS: We found 3 independent variables significantly associated with death in patients with community-acquired pneumonia requiring mechanical ventilation: simplified acute physiological score greater than 45 (odds ratio, 5.5 [95% confidence interval, 1.7-12.3]), shock (odds ratio, 5.7 [95% confidence interval, 1.7-10.1]), and acute renal failure (odds ratio, 3.0 [95% confidence interval, 1.1-4.0]). There was no statistically significant difference in ICU mortality among patients with or without community-acquired pneumonia (32% vs 35%; P=.59). CONCLUSIONS: Community-acquired pneumonia needing mechanical ventilation is not a disease associated with higher mortality. The main determinants of patient outcome were initial severity of illness and the development of shock and/or acute renal failure.
- Use of sedatives and neuromuscular blockers in a cohort of patients receiving mechanical ventilation.Publication . Arroliga, A; Frutos-Vivar, F; Hall, J; Esteban, A; Apezteguía, C; Soto, L; Anzueto, A; Freitas, PT; International Mechanical Ventilation Study Group.OBJECTIVE: To describe the use of sedatives and neuromuscular blocking agents (NMBs) and their impact in outcome in an international cohort of patients receiving mechanical ventilation. METHODS: We analyzed the database of a prospective, multicenter cohort of 5,183 adult patients who received mechanical ventilation for > 12 h. We considered that a patient received a given agent when it was administered for at least 3 h in a 24-h period. RESULTS: A total of 3,540 patients (68%; 95% confidence interval [CI], 67 to 69%) received a sedative at any time while receiving mechanical ventilation. The median number of days of use was 3 (interquartile range [IQR], 2 to 6 days). The persistent use of sedative was associated with more days of mechanical ventilation (median, 4 days [IQR, 2 to 8 days], vs 3 days [IQR, 2 to 4 days] in patients who did not receive sedatives [p < 0.001]); more weaning days (median, 2 days [IQR, 1 to 3 days], vs 2 days [IQR, 1 to 5 days] in patients who did not receive sedatives [p < 0.001]); and longer length of stay in the ICU (median, 8 days [IQR, 5 to 15 days], vs 5 days [IQR, 3 to 9 days] in patients who did not receive sedatives [p < 0.001]). Six hundred eighty-six patients (13%; 95% CI, 12 to 14%) received an NMB for at least 1 day. The median number of days of use was 2 (IQR, 1 to 4 days). The administration of an NMB was independently related with age, a normal previous functional status, main reason of mechanical ventilation (patients with ARDS received more NMBs), and with patient management (patients requiring permissive hypercapnia, prone position, high level of positive end-expiratory pressure, and high airways pressure). CONCLUSIONS: The use of sedatives is very common, and their use is associated with a longer duration of mechanical ventilation, weaning time, and stay in the ICU. NMBs are used in 13% of the patients and are associated with longer duration of mechanical ventilation, weaning time, stay in the ICU, and higher mortality.
- Outcome of mechanically ventilated patients who require a tracheostomyPublication . Frutos-Vivar, F; Esteban, A; Apezteguía, C; Anzueto, A; Nightingale, P; González, M; Soto, L; Rodrigo, C; Raad, J; David, C; Matamis, D; D'Empaire, G; Freitas, PT; International Mechanical Ventilation Study GroupOBJECTIVE: To estimate the prevalence of, the risk factors associated with, and the outcome of tracheostomy in a heterogeneous population of mechanically ventilated patients. DESIGN: Prospective, observational cohort study. SETTING: A total of 361 intensive care units from 12 countries. PATIENTS: A cohort of 5,081 patients mechanically ventilated for >12 hrs. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 546 patients (10.7%) had a tracheostomy during their stay in the intensive care unit. Tracheostomy was performed at a median time of 12 days (interquartile range, 7-17) from the beginning of mechanical ventilation. Variables associated with the performance of tracheostomy were duration of mechanical ventilation, need for reintubation, and neurologic disease as the primary reason of mechanical ventilation. The intensive care unit stay of patients with or without tracheostomy was a median of 21 days (interquartile range, 12-32) vs. 7 days (interquartile range, 4-12; p < .001), respectively, and the hospital stay was a median 36 days (interquartile range, 23-53) vs. 15 days (interquartile range, 8-26; p < .001), respectively. Adjusting by other variables, tracheostomy was independently related with survival in the intensive care unit (odds ratio, 2.22; 95% confidence interval, 1.72-2.86). Mortality in the hospital was similar in both groups (39% vs. 40%, p = .65). CONCLUSIONS: Tracheostomy is a common surgical procedure in the intensive care unit that is associated with a lower mortality in the unit but with a longer stay and a similar mortality in the hospital than in patients without tracheostomy
- Endocardite das válvulas das cavidades direitas: a importância da ecocardiografia na identificação da(s) estrutura(s) afectada(s)Publication . Ricardo, J; Garcia, A; Leite, A; Serra, I; Revés, L; Miranda, C; Freitas, A; Freitas, PTA endocardite das válvulas das cavidades direitas do coração é rara. Ocorre geralmente em doentes com toxicofilia endovenosa, portadores de pacemaker (PMD), portadores de próteses valvulares ou cateter venoso central e ainda em doentes com cardiopatias congénitas. A Ecocardiografia constitui o gold standard na identificação da(s) estrutura(s) afetada (s) e permite a orientação terapêutica. Apesar de ser rara, a endocardite das cavidades direitas deve ser tida em conta durante a realização de ecocardiografia transtorácica e/ou transesofágica que vise o diagnóstico de endocardite. A profilaxia antibiótica deve ser sempre aplicada antes da realização de qualquer procedimento invasivo de acordo com as recomendações publicadas. Acentua-se a necessidade de educar a população, prevenindo-se assim complicações graves resultantes de procedimentos simples cada vez mais vulgares nas populações mais jovens, como a colocação de piercing. Os autores apresentam dois casos clínicos dessa patologia.
- Ascite biliar: a propósito de dois casos clínicosPublication . Gomes, A; Sousa, M; Pignatelli, N; Rocha, F; Freitas, PT; Nunes, VAscite biliar é um achado pouco frequente entre os doentes com ascite. Está muitas vezes associada a lesões do tubo digestivo e/ ou da árvore biliopancreática. São descritos dois casos clínicos de doentes de idade jovem internados na UCIP, com antecedentes de consumo regular de bebidas alcoólicas, admitidos com o diagnóstico de pancreatite aguda e de pancreatite crónica agudizada, respectivamente. Ambos evoluíram com ascite e derrame pleural. A paracentese revelou líquido de características biliares, com elevada contagem celular, com elevação de bilirrubina e LDH. Num dos casos atribuiu-se a ascite à inflamação pancreática e peripancreática, tendo evoluído favoravelmente sob terapêutica conservadora. No outro caso colocou-se a hipótese diagnóstica de perfuração da vesícula biliar que se confirmou intraoperatoriamente. A discussão clínica interdisciplinar foi determinante na procura de diagnósticos pouco frequentes e na adequada abordagem terapêutica, médica e cirúrgica, respectivamente.
- “Saúde para todos”: cooperação em saúde com São Tomé e PríncipePublication . Freitas, PTO Instituto Marquês de Valle Flor (IMVF) é uma Organização Não Governamental (ONG) fundada em 1951, que actua em São Tomé e Príncipe desde 1988. Está presente em todos os países da Comunidade dos Países de Língua Portuguesa (CPLP) e gere mais de quarenta projectos de cooperação na área da saúde, segurança alimentar, infra-estruturas e educação
- Dor e analgesia em doente críticoPublication . Ferreira, N; Miranda, C; Leite, A; Revés, L; Serra, I; Fernandes, AP; Freitas, PTA detecção, quantificação e tratamento da dor em doente crítico é, à longa data, uma preocupação dos clínicos que tra- balham em Unidades de Cuidados Intensivos. Não obstante, a dor é frequente em doentes críticos, independentemente do seu critério de admissão. Os autores apresentam uma revisão sobre analgesia em doente critico enfatizando o recurso a escalas apropriadas para o seu diagnóstico, quantificação e avaliação de terapêuticas efetuadas. São descritas as abordagens farmacológicas (sistémicas e regionais) recomendadas e discute-se a evolução do evento doloroso agudo a crónico em contexto de cuidados intensivos.